Synthetic Route of 128071-75-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.128071-75-0, name is 2-Bromonicotinaldehyde, molecular formula is C6H4BrNO, molecular weight is 186.01, as common compound, the synthetic route is as follows.
General procedure: To a solution of 2-bromobenzaldehyde (1a, 1 mmol) and 1H-pyrazol-5-amine (2a, 1.2 mmol) in DMF (5 mL) were added K2CO3 (2 mmol), CuI (0.2 mmol) and ethylenediamine(0.2 mmol). The mixture was stirred at 110 C until a complete conversion as indicated by TLC. It was cooled to room temperature and added with saturated brine, then extracted with ethyl acetate. The combined organic phase was concentrated under vacuum. The crude product was purified by columnchromatography eluting with petroleum ether/ethyl acetate (10:1) to give the desired product 3a. Products 3b-3ll were obtained in a similar manner.
Statistics shows that 128071-75-0 is playing an increasingly important role. we look forward to future research findings about 2-Bromonicotinaldehyde.
Reference:
Article; Gao, Lin; Song, Yunping; Zhang, Xinying; Guo, Shenghai; Fan, Xuesen; Tetrahedron Letters; vol. 55; 36; (2014); p. 4997 – 5002;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem