Related Products of 126954-66-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 126954-66-3, name is 2,5-Dichloronicotinonitrile. A new synthetic method of this compound is introduced below.
To a solution of 2,5-dichloronicotinonitrile (160 mg, 0.92 mmol) in n-butanol (15.0 mL) was added hydrazine hydrate (0.4 mL, 15 mmol). The mixture was stirred at 120 C for 7 h. The reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 4/1) to give the title compound as a white solid (86 mg, 55 %).MS (ESI, pos. ion) m/z: 169.0 [M+H]?H NIVIR (400 MHz, CDC13) (ppm): 8.33 (s, 1H), 8.29 (s, 1H), 5.69 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,126954-66-3, 2,5-Dichloronicotinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (215 pag.)WO2018/127096; (2018); A1;,
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