Synthetic Route of 128071-98-7 ,Some common heterocyclic compound, 128071-98-7, molecular formula is C5H3BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 4-bromo-2-fluoropyridine (0.635 g), Pd2(dba)3 (catalytic quantity), Xantphos (catalytic quantity) and Cs2CO3 (1.5 g) in 1,4-dioxane (5ml) was degassed by applying alternating N2 atmosphere and vacuum. Intermediate (132) in 1,4-dioxane (15ml) was added under N2-atmosphere. The reaction mixture was stirred at 1000C for 2 hours. The reaction mixture was filtrated. After extraction (DCM/water), the collected organic layers were dried (MgSO4), filtered and the filtrate was evaporated. The residue was purified by HPLC (HPLC method A). Two product fraction groups were collected and their solvents were evaporated, yielding intermediate (133) (trans; relative; mixture) and intermediate (134) (cis; relative; mixture).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 128071-98-7, 4-Bromo-2-fluoropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2008/3665; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem