Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine. A new synthetic method of this compound is introduced below., COA of Formula: C5Cl2F3N
General procedure: A mixture of commercially available 3,5-dichloro-2,4,6-(trifluoro)pyridine 1 (1 mmole), aryl boronic acids 2a-i (2.2 mmol), Pd(OAc)2 (2 mol %), x-phos (5 mol %), and K3PO4 (1.5 mmole) was added into a solution of H2O/DMF (1:1) (2 mL) in pressure tubes. The reaction mixture was stirred at 60-80C for 12 hrs. After completion of reaction (TLC controlled), the organic and aqueous layers were separated and the latter was extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried (Na2SO4), filtered, and the filtrate was concentrated in vacuo. The product was purified by column chromatography (silica gel, EtOAc/heptane). All products were characterized by NMR, GC-MS, HRMS, and IR spectroscopic techniques.
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Reference:
Article; Sharif, Muhammad; Shoaib, Khurram; Ahmed, Shahzad; Iqbal, Jamshed; Abilov, Zharylkasyn A.; Spannenberg, Anke; Langer, Peter; Tetrahedron Letters; vol. 57; 29; (2016); p. 3060 – 3062;,
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