Synthetic Route of 89283-92-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89283-92-1, name is 5-Bromo-4-chloropyridin-3-amine. A new synthetic method of this compound is introduced below.
To a solution of 43.1 (1 .3 g, 4.61 mmol), 5-bromo-4-chloropyridin-3-amine (1 .004 g, 4.84 mmol), Na2C03 (0.977 g, 9.22 mmol), Pd(PPh3)2CI2 (0.323 g, 0.461 mmol) in 2-Propanol (25 mL) was added water (8 mL). The mixture was stir at 100 °C for 2 hr under nitrogen protection. Then the mixture was diluted with DCM, washed with water, brine. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by CombiFlash, eluted with methanol in DCM (0-5percent, 30 min). Collected the desired fraction and concentrated in vacuum to afford the title compound (1 .1 g, 84percent) as off-white solid. 1 H NMR (400 MHz, DMSO-d6) delta 11.89 (d, J = 2.6 Hz, 1 H), 8.07 (s, 1 H), 7.84 (s, 1 H), 7.81 (s, 1 H), 7.72 (d, J = 2.5 Hz, 1 H), 7.49 (s, 1 H), 5.73 (s, 2H), 2.56 (s, 3H). LC-MS: [M+H]+ = 283.1 , 285.1 .
At the same time, in my other blogs, there are other synthetic methods of this type of compound,89283-92-1, 5-Bromo-4-chloropyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; DU-CUNY, Lei; XIAO, Qitao; XUN, Guoliang; ZHENG, Qiangang; (204 pag.)WO2018/234978; (2018); A1;,
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