With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147149-98-2, name is 4-Amino-2-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, molecular weight is 162.11, as common compound, the synthetic route is as follows.SDS of cas: 147149-98-2
To a solution of 2,4-dichloro-6-(4- (trifluoromethyl)pyrimidin-2-yl)-l,3,5-triazine (981 mg, 3.31 mmol) in THF (80 mL) was added 2-(trifluoromethyl)pyridin-4-amine (590 mg, 3.64 mmol) and NaHC03 (556 mg, 6.6 mmol). The mixture was stirred at refluxing for 18 hours. The mixture was concentrated and poured to water, extracted with ethyl acetate, dried over sodium sulphate, filtered and concentrated to give a residue, which was purified by Si02 chromatography to give 4-chloro-6-(4-trifluoromethyl- pyrimidin-2-yl)-[l,3,5]triazin-2-yl]-(2-trifluoromethyl-pyridin-4-yl)-amine. LCMS: m/z 422.2 (M+H)+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy; UTLEY, Luke; WO2015/6592; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem