Reference of 73870-24-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73870-24-3, name is 4-(Bromomethyl)pyridine hydrobromide, molecular formula is C6H7Br2N, molecular weight is 252.93, as common compound, the synthetic route is as follows.
[00385] To a mixture of 53-1 (60 mg, 0.187 mmol, 1.00 eq) and 53-2 (85 mg, 0.336 mmol, 1.80 eq, HBr) in DMF (3 mL) was added K2C03 (100 mg, 0.723 mmol, 3.87 eq) in one portion at 25C. The mixture was stirred at 80 C for 3.5 h. LCMS showed the starting material was consumed completely and one main peak with the desired MS was detected. TLC showed one new spot was formed. The reaction mixture was extracted with EtOAc (40 mL) and washed with brine (30 mL*4). The organic layer was dried with anhydrous Na2S04, filtered, and concentrated under vacuum. The residue was purified by flash silica gel chromatography and then by prep-HPLC (basic condition) to provide the title compound (11.77 mg, 28.5 umol, 15.3% yield). LCMS (ESI): RT = 1.120 min, mass calc. for C20Hi5F3N6O 412.13, m/z found 413.0[M+H]+. 1HNMR (400MHz, DMSO-i_) 58.65- 8.55 (m, 3H), 8.01 (d, J=8.00 Hz, 1H), 7.47 – 7.37 (m, 2H), 7.33 (br d, J=5.20 Hz, 2H), 7.30 – 7.24 (m, 2H), 7.23- 7.17 (m, 2H), 7.06 (t, J=6.80 Hz, 1H), 6.12 (s, 2H).
Statistics shows that 73870-24-3 is playing an increasingly important role. we look forward to future research findings about 4-(Bromomethyl)pyridine hydrobromide.
Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (396 pag.)WO2018/204532; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem