Application of 136888-20-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 136888-20-5, name is 5-Fluoro-3-nitropyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
A suspension of S-fluoro-3-nitropyridin-2-ol (500 mg, 3.16 mmol) and cesiumcarbonate (2061 mg, 6.33 mmol) in DMF (8 mL) was stirred at rt for 10 mm, and 1-bromo-2-fluoroethane (723 mg, 5.69 mmol) was then added. The mixture was stirred at75 C for 4 h. Two products with the desired MS were detected. The mixture was dilutedwith ethyl acetate (15 mL) and filtered through Celite. The filtrate was concentratedunder vacuum to dryness. The residue was dissolved in ethyl acetate (100 mL), washedwith water (20 mL) and brine (20 mL), and dried over anhydrous Mg504. The desired product, 5 -fluoro- 1 -(2-fluoroethyl)-3 -nitropyridin-2( 1 H)-one (146 mg, 0.715 mmol, 22.61 % yield), was isolated as a yellow solid by ISCO (40 g solica gel, 30-50% ethyl acetate/hexane).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,136888-20-5, 5-Fluoro-3-nitropyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem