In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87109-10-2, name is 3-Phenylpyridin-2-amine, the common compound, a new synthetic route is introduced below. Formula: C11H10N2
General procedure: To a solution of a2-aminopyridine derivative 2 or 4 (0.9 mmol) in absolute EtOH(5 mL) was added dropwise ethyl 4,4,4-trifluorobutynoate 1 (230 mg, 1.4 mmol). The mixturewas stirred at room temperature for 30 minutes before an additional portion of 1 (150 mg, 0.9 mmol) was added. The reaction mixture was stirred at room temperature untilcompletion of the reaction. The solvent was then evaporated under reducedpressure and the residue was triturated with Et2O (20 mL) andfiltered off to afford the expected pyrido[1,2-a]pyrimidin-2-ones 3.
The synthetic route of 87109-10-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; Enguehard-Gueiffier, Cecile; Abarbri, Mohamed; Silvestre, Anne; Petrignet, Julien; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 114 – 120;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem