Synthetic Route of 875781-15-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 875781-15-0, name is 5-Bromo-2-fluoronicotinaldehyde, molecular formula is C6H3BrFNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 5-bromo-2-fluoro-pyridine-3-carbaldehyde (200.0 mg, 0.980 mmol, 1.0 eq.) and (4-fluorophenyl)hydrazine hydrochloride (159.4 mg 0.980 mmol, 1.0 eq.) in NMP (3.0 mL) was stirred at ambient temperature for two hours, before caesium carbonate (958.3 mg, 2.941 mmol, 3.0 eq.) was added and the mixture was heated to 115 C. for 1 hour. The mixture was cooled to ambient temperature, and was diluted with water/EtOAc. The layers were separated, and the aqueous layer was extracted two more times with EtOAc. The combined organic layers were then washed with brine and were dried over MgSO4. The solvent was removed under reduced pressure and the remains were purified using silica gel chromatography to obtain 184.4 mg (64%) of 5-bromo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 875781-15-0, 5-Bromo-2-fluoronicotinaldehyde.
Reference:
Patent; Gruenenthal GmbH; JAKOB, Florian; ALEN, Jo; KRUeGER, Sebastian; SCHADE, Markus; FRIEBE, Daniela; HENNEN, Stephanie; US2019/185470; (2019); A1;,
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