Electric Literature of 931105-37-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 931105-37-2, name is Methyl 5-bromo-2-fluoronicotinate. This compound has unique chemical properties. The synthetic route is as follows.
To an oven-dried 10 mL vial were added methyl 5-bromo-2-fluoronicotinate (1 g, 4.27 mmol), bis(pinacolato)diboron (217 mg, 0.854 mmol) and potassium acetate (1.258 g, 12.82 mmol). 1,4-Dioxane (20 mL) was introduced into the vial and nitrogen gas was blown through for 10 min. PdCl2(dppf) (0.156 g, 0.214 mmol) was added to the reaction mixture and degassing continued for 10 min. The mixture was heated to reflux at 80 C ON. The reaction mixture was filtered through a pad of Celite to remove the catalyst, and the filter cake was washed with EtOAc twice. The obtained organic solutions were concentrated. The crude residue was purified by flash column chromatography (ISCO, 80 g silica gel column, 20-50% EtOAc/hexanes) to yield methyl 2-fluoro-5-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate (1 g, 3.56 mmol, 83 %) as a white solid. MS ESI m/z 200.0 (M+H for the boronic acid)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 931105-37-2, Methyl 5-bromo-2-fluoronicotinate.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; DZIERBA, Carolyn Diane; GONG, Hua; GUERNON, Jason M.; GUO, Junqing; HART, Amy C.; LUO, Guanglin; MACOR, John E.; PITTS, William J.; SHI, Jianliang; VENABLES, Brian Lee; WEIGELT, Carolyn A.; WU, Yong-Jin; ZHENG, Zhizhen Barbara; SIT, Sing-Yuen; CHEN, Jie; (810 pag.)WO2019/147782; (2019); A1;,
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