The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89878-14-8, name is 3-(Diethylboryl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
3-bromo ANISOTE (17.4g, 93.03 mmol) was dissolved in 650 mL tetrahydrofuran and 210 mL water in a 2L round bottom flask equipped with a magnetic stirrer. Diethyl- (3-pyridyl) borane (15. 73g, 106.99 MMOL), sodium carbonate (44.4g, 418.64 mmol) and dichlorobis (triphenylphosphine) palladium (II) (9.8g, 13.95 mmol) were added and the mixture heated at reflux for 4 h then cooled to ambient temperature. The mixture was diluted with 300 mL water and extracted with diethyl ether (2 x 300 mL). The extracts were combined and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resultant oil was purified by flash chromatography (1: 1 ethyl acetate/hexanes). Product fractions were concentrated under reduced pressure to yield 17.75g (99%) of the desired compound as a pale yellow oil. MS (APCI) 186.1 (M + H) +. 1H NMR (400 MHz, CDCI3) 8 8. 85 (d, 1 H), 8.60 (d, 1 H), 7.92 (dd, 1 H), 7.39 (m, 2H), 7.13 (dd, 1H), 7.08 (t, 1H), 6.94 (dd, 1H), 3.85 (s, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 89878-14-8.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/48334; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem