Electric Literature of 54127-30-9, Adding some certain compound to certain chemical reactions, such as: 54127-30-9, name is (5,6-Dichloropyridin-3-yl)methanol,molecular formula is C6H5Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54127-30-9.
2,3-Dichloro-5-formylpyridine. To a 500 mL round-bottom flask, manganese oxide (43.5 g, 0.50 mol) was added to a solution of 2,3-dichloro-5-hydroxylmethylpyridine (64, 8.10 g, 50.0 mmol) in anhydrous CH2CIo ( 150 mL). The reaction mixture was stirred at a temperature of about 250C for 48 h, filtered through CELITE, and concentrated under reduced pressure. The mixture was chromatographed by a silica gel chromatography column eluting with a gradient of ethyl acetate (0%-40%)/hexanes to provide 7.2 g of 65 (90% yield). 1H NMR (400 MHz, CDCl3) delta 10.08 (IH, s), 8.77 (I H, d, J=1.97 Hz), 8.25 (IH, d, J=1.97 Hz). LC/MS (M+1 ): 176.
According to the analysis of related databases, 54127-30-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PURDUE PHARMA L.P.; SHIONOGI & CO., LTD.; WO2008/132600; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem