Related Products of 1136-52-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol, molecular formula is C11H15NO3, molecular weight is 209.24, as common compound, the synthetic route is as follows.
Anhydrous THF (200 ml) was added to NaH (60%, 24 g, 600 mmol) at O0C under a nitrogen atmosphere. To this suspended mixture a solution of 2, 2, 8-trimethyl-4H- [l,3]dioxino[4,5-c]pyridin-5-yl)methanol (32.0 g, 150 mmol) in 400 ml of THF (J. Med Chem., 1977, 20, p745) was added. The resulting mixture was refluxed for 30 min; a significant amount of precipitate accumulated during the reflux. After cooling to room temperature, /j-methoxybenzyl chloride (23.5 g, 150 mmol) was introduced drop-wise and the resulting mixture was refluxed for another 8 h. The reaction was quenched carefully by adding ice-cold water to the viscous mixture at O0C and diluted with a saturated ammonium chloride solution followed by extraction with methylene chloride. The combined organic extracts were washed with brine, dried (NaaSCU), and concentrated yielding a brown oil. The crude product was purified by chromatography (10% ethyl acetate/petroleum ether) yielding 25.0 g of compound 17a (50% yield); LC-MS (M+H)+ m/z 331.
The chemical industry reduces the impact on the environment during synthesis 1136-52-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AMBRILIA BIOPHARMA INC.; WO2009/146555; (2009); A1;,
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