Adding a certain compound to certain chemical reactions, such as: 1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1822-51-1, blongs to pyridine-derivatives compound. Recommanded Product: 1822-51-1
To a mixture of diethyl 2-(((3af?,5f?,6/?,daf?)-6-acetoxy-6-ethynyl-2,2-dimethyltetra- hydrofuro[2,3-i/][l,3]dioxol-5-yl)methoxy)malonate (1.2 g, 2.90 mmol, 1 eq) in DMF (20 mL) at 20 C was added CS2CO3 (6.60 g, 20.27 mmol, 7 eq) and 4-(chloromethyl) pyridine hydrochloride (1.90 g, 11.58 mmol, 4 eq). The mixture was stirred for 2 h before it was filtered and the filter cake was washed with EtOAc (20 mL). The filtrate was diluted with water (60 mL) and extracted with EtOAc (3 x 50 mL). The combined extract was washed with water (2 x 50 mL), saturated aq. MLCl (50 mL), brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on S1O2 (14-33% EtOAc in petroleum ether) to give diethyl 2- (((3ciR,5R, 6A*, A/ri>)-6-acetoxy-6-ethynyl-2,2-dimethyltetrahydrofuro[2,3-6/][ l ,3]-dioxol-5- yl)methoxy)-2-(pyridin-4-ylmethyl)malonate (900 mg, 61% yield) as a yellow oil
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; CALITHERA BIOSCIENCES, INC.; CHEN, Lijing; BILLEDEAU, Roland, Joseph; LI, Jim; (437 pag.)WO2019/246403; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem