Synthetic Route of 61337-89-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61337-89-1, name is 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol, molecular formula is C17H21N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 3 Preparation of mirtazapine (I) from 1-(3-hydroxymethylpyridyl-2)-2-phenyl-4-methylpiperazine 100 ml of concentrated sulfuric acid was cooled to about 15 C. 50 grams (0.18 mole) of 1-(3-hydroxymethylpyridyl-2)-2-phenyl-4-methylpiperazine was added slowly to the sulfuric acid, and the temperature was maintained below 20 C. The temperature was then raised to 30 C., and the reaction mixture was stirred for 12 hours maintaining the temperature between 25 C. to 30 C. The reaction mass was then quenched in 1 liter of ice cold water. The pH of the reaction mixture was adjusted to about 10-11 using 20% to 25% aqueous ammonia solution while maintaining the temperature below 30 C. 500 ml of ethylacetate was added to the reaction mixture and stirred for about 15 minutes at 30 C. The layers were separated, and the aqueous layer was back extracted with 100 ml of ethylacetate. All the ethylacetate extracts were combined together and heated to reflux under stirring. 5 grams of activated charcoal was added, and the reaction mixture was stirred under reflux temperature for 30 minutes. The reaction mixture was filtered hot over a hyflo bed. 1.6 ml of water was added to the clear filtrate and heated to about 50 C. The reaction mass was stirred at 50 C. for 30 minutes and then concentrated under vacuum to keep about 100 ml of ethylacetate in the reaction mixture. 150 ml of isopropyl ether was added to the reaction mass and heated to reflux. 5 grams of activated carbon was added, and the reaction mixture was stirred under reflux for 30 minutes. The reaction mixture was filtered hot over a hyflo bed. The clear filtrate was cooled under stirring to about 30 C. and further chilled to about 5 C. The reaction mass was stirred at 5 C. to 10 C. for 1 hour. The resulting solid crystals were filtered and washed with 25 ml of chilled isopropyl ether. The product obtained was suck dried for 30 minutes and then dried at 65 C. under vacuum to get 40 grams of mirtazapine having HPLC purity of more than 99.8%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 61337-89-1, 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol.
Reference:
Patent; WATSON PHARMA PRIVATE LIMITED; US2011/201804; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem