Analyzing the synthesis route of 5349-17-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7Br2NO

Preparation of 2-Methyl-5-nitro-phenyl)-(5-pyridin-4-yl-oxazol-2-yl)-amineTo a solution of 4-bromoacetylpyridine hydrobromide (5 g, 17.8 mmol) in 😯 mL of water was added sodium azide (1.16 g, 17.8 mmol) and the contents stirred at room temperature for 30 min. The reaction mixture was cooled to O0C, treated slowly with saturated aqueous NaHCO3 until pH=6-7, extracted with dichloromethane (3×3 OmL) and the combined organic phases were dried over MgSO4, concentrated at room temperature under reduced pressure to a final volume of 25 mL, and diluted with dioxane (30 mL). The resulting solution was concentrated to remove the remaining EPO (lower boiling) dichloromethane. To the final volume (25 mL) was added at O0C, 2- methyl-5-nitrophenyl isocyanate (1.58 g, 8.9 mmol) (commercially available) and portion wise triphenylphosphine (2.62 g, 8.9 mmol). The reaction mixture was then stirred for 1 h at room temperature and heated for an additional 2 h at 100C. After evaporation of the solvent under reduced pressure the residue was crystallized in dichloromethane/ethanol (10mL/5mL), to give the title compound as yellow crystals (0.9 g, 34%). m p > 220 C

With the rapid development of chemical substances, we look forward to future research findings about 5349-17-7.

Reference:
Patent; AB SCIENCE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); INSTITUT CURIE; WO2006/106437; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem