The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 571189-49-6, name is 5-(4-Methylpiperazin-1-yl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
5-(4-Methylpiperazin-1-yl)pyridin-2-amine (35.6 mg, 0.185 mmol) was taken up in dry1 ,4-dioxane (2 mL) under argon. tert-Butyl 1 -(2-chloropyrimidin-4-yl)-2-oxo- 1,3 – diazaspiro[4.Sjdecane-3-carboxylate (4) (65 mg, 0.18 mmol) was added followed by cesiumcarbonate (0.173 g, 0.532 mmol) and rac-2,2?-bis(diphenylphosphino)-l,l?-binaphthyl (11.0 mg, 0.0177 mmol). Finally, palladium acetate (3.98 mg, 0.0177 mmol) was added and the mixture was sparged with argon for 20 mm, the flask fitted with a condenser and the reaction mixture heated at 100 C for 30 minutes. The reaction mixture was cooled to ambient temperature, filtered through a pad of Celite rinsing with ethyl acetate and the solvent wasremoved in vacuo to afford a dark yellow foam. Addition of water caused the product to precipitate. The solids were removed by filtration and washed with water. Drying under nitrogen affords 52 mg (56% yield) of the desired product 5 as a dark yellow solid.MS (ESI+) for C27H38N803 m/z 523.6 (M+H)5
With the rapid development of chemical substances, we look forward to future research findings about 571189-49-6.
Reference:
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; GASTON, Ricky, D.; GADWOOD, Robert, C.; (177 pag.)WO2018/5533; (2018); A1;,
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