Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14667-47-1, name is Methyl 2-aminonicotinate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H8N2O2
Solid phosgene (3.6 mmol) and 1,4-dioxane (20 mL) were added to the reaction flask and cooled to 0 C.Slowly add and stir6-Amino-2,2,7-trifluoro-4-(4-methoxybenzyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (8 mmol)And 20 mL of a 1.4-dioxane composition solution.After the system was further stirred at this temperature for 30 min, it was heated to reflux for 10 h.The system was cooled to room temperature and dry nitrogen was introduced into the solution for 1 h. To the system was added 2-aminonicotinate methyl ester (8 mmol), and the system was further heated to reflux for 6 h.After the reaction is completed, the system is cooled to room temperature, a solid is precipitated, and suction filtration is performed.After washing with ether,Drying light brown solid 4.39g,Yield: 85%.
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Reference:
Patent; Shandong Xian Da Agrochemical Co., Ltd.; Xi Zhen; Wang Xianquan; Wang Dawei; (28 pag.)CN108727367; (2018); A;,
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