Synthetic Route of 504-24-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-24-5, name is 4-Aminopyridine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-OAP was prepared using the Chichibabin reactionof 4-aminopyridine (4-AP) and sodium amide indry dioxane, followed by alkylation with octyl iodide[25]. 4-OAP was isolated from the reaction mixture viaextraction with hexane and recrystallized first fromhexane and then from acetone (99.9%, m.p. 64 ±0.2C). The molecular and structural formulas wereconfirmed via elemental analysis plus IR and 1HNMR spectroscopy. OAP chloride was prepared byshaking a 0.1 M solution of 4-OAP (100 mL) with 1 MHCl (100 mL). The organic phase was separated andfiltered through a paper filter. All chloroform wasevaporated under an air stream. The residue was driedat 60C. The yield was 95%. According to the datafrom potentiometric titration, the content of the mainsubstance was 99.8%.
According to the analysis of related databases, 504-24-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Borshch; Ageeva; Frolova, A. Yu.; Russian Journal of Physical Chemistry; vol. 93; 5; (2019); p. 828 – 834; Zh. Fiz. Khim.; vol. 93; 5; (2019); p. 661 – 667,7;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem