The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 571188-59-5
5)Synthesis of Compound 18: 490mg 4-(6-amino-pyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester was added to 15ml of anhydroustoluene. The system was cooled to 0 C. 1.05eq LiHMDS was added dropwise. Aftercompletion of the dropwise addition, reaction was continued for 30min at roomtemperature. After the completion of the reaction, the system was cooled to 0 C. A solution of 5ml toluene containing 300mg ofCompound 17 was added dropwise. After the completion of the dropwise addition,the reaction was warmed to room temperature and reacted for 40min. After thecompletion of the reaction, the system was cooled to 0 C, and saturated NH4Clsolution was added to quench the reaction. After liquid separation, the organicphase was concentrated. Ethyl acetate was added and the system was filtered togive 470mg yellow solid as Compound 18.
With the rapid development of chemical substances, we look forward to future research findings about 571188-59-5.
Reference:
Patent; Tetranov Biopharm, LLC; Wu, Yusheng; Niu, Chengshan; Zou, Dapeng; Zhang, Sen; Guo, Ruiyun; Li, Jingya; (24 pag.)CN104447739; (2016); B;,
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