Adding a certain compound to certain chemical reactions, such as: 106447-97-6, 2-Amino-4-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Weighing N-bromo succinimide (1.12g, 6 . 3mmol) is added to thf (7.25 ml) in, cooling to 0 C, the 4 – (trifluoromethyl) pyridin-2-amine (0.97g, 6mmol) dissolved in tetrahydrofuran (5.75 ml) in, dropping slowly added to the above-mentioned solution, keeping the temperature at 0 C, after dripping, slowly to room temperature, stirring 0.5 hours, adding sodium thiosulfate (0.25g) aqueous solution (4.75 ml) quenching, concentrated, crude product by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) purification, to obtain the title compound (1.2g, yield 83.3%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,106447-97-6, 2-Amino-4-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; Shandong Xuanzhu Oharma Co., Ltd.; Wu, Yongjian; (47 pag.)CN105541792; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem