Adding a certain compound to certain chemical reactions, such as: 131747-61-0, (2-(Trifluoromethyl)pyridin-4-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 131747-61-0, blongs to pyridine-derivatives compound. Recommanded Product: (2-(Trifluoromethyl)pyridin-4-yl)methanol
534 tert-Butyl N-[(3-hydroxyphenyl)methyl]carbamate (0.18 g, 1.0 mmol), E-1 (0.22 g, 1.0 mmol) and 13 triphenylphosphine (0.39 g, 1.5 mmol) were dissolved in 12 dichloromethane (3 mL), 236diisopropyl azodicarboxylate (0.32 mL, 1.5 mmol) was added, and the mixture was stirred at roomtemperature for 1 hr. The reaction mixture was concentrated under reduced pressure and the obtained residuewas purified by silica gel column chromatography (hexane/ethyl acetate). To the obtained compound wasadded 4 mol/L 114 hydrochloric acid (1,4-dioxane solution, 3 mL), and the mixture was stirred at roomtemperature for 1 hr, and concentrated under reduced pressure to give the 535 title compound ( 0.13 g ,0.40 mmol, 40%) MS (ESI) m/z 283 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-61-0, its application will become more common.
Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
Pyridine – Wikipedia,
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