With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.624-28-2, name is 2,5-Dibromopyridine, molecular formula is C5H3Br2N, molecular weight is 236.892, as common compound, the synthetic route is as follows.Recommanded Product: 2,5-Dibromopyridine
The suspension of 11a (3.12g, 13.11mmol) in 15mL of morpholine was reacted under microwave condition for lOOmin at 12O0C. After the reaction was complete, 20OmL of ethyl acetate was added. The resulting solution was washed with 0.1N HCl (5OmL), water (10OmL), 0.1N NaOH (5OmL) and water (10OmL) subsequently. The resulting organic layer was dried over anhydrous Na2SCK and evaporated to provide lib (3.19g, 99.7%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,624-28-2, 2,5-Dibromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; XCOVERY, INC.; WO2008/88881; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem