Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 71701-92-3, name is 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H2BrClF3N
n-BuLi (1.57M solution in hexane; 64 ml_, 0.10 mol) is added dropwise to a solution of 3- bromo-2-chloro-5-trifluoromethylpyridine (20.00 g, 0.077 mol), DMF (7.72 ml_, 0.10 mol) in toluene (400 ml_) at -650C. After stirring at the same temperature for 30 min, the mixture is quenched by addition of 1 N HCI and extracted with ethyl acetate. The organic layer is washed with water, brine, dried over magnesium sulfate, filtered and concentrated to give crude 2-chloro-5-trifluoromethylpyridine-3-carbardehyde.
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Reference:
Patent; NOVARTIS AG; WO2008/58967; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem