Reference of 74115-12-1 , The common heterocyclic compound, 74115-12-1, name is 5-Chloro-3-hydroxypyridine, molecular formula is C5H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 14; Preparation of 3-chloro-N-[(lS)-1-(4-chlorophenyl) ethyl]-5-(methoxymethoxy)-4-pyridine- carboxamide (Compound 179); Step A: Preparation of 3-chloro-5- (methoxymethoxy) pyridine; To a solution of 5-chloro-3-hydroxypyridine (Aldrich, 5 g, 39 mmol) in acetonitrile (60 mL) was added chloromethyl methyl ether (3.11 g, 39 mmol) followed by potassium carbonate (10.78 g). The mixture was heated at 60 C for 18 h and then diluted with water (100 mL). The aqueous layer was extracted with ethyl acetate (4 x 100 mL). The combined organic layers were dried (MgSO4), and the solvent was evaporated under reduced pressure to leave the title compound as a yellow oil (5.5 g). 1H NMR (CDC13) 8 3.49 (s, 3H), 5.30 (s, 2H), 7.42 (s, 1H), 8.26 (s, 1H), 8. 31 (s, 1H)
The synthetic route of 74115-12-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; E.I. DUPONT DE NEMOURS AND COMPANY; WO2005/70889; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem