Synthetic Route of 111669-25-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111669-25-1, name is 1-Boc-4-(3-Aminopyridin-2-yl)piperazine, molecular formula is C14H22N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 34.1 : 4-(3-Ethylamino-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester. To a mixture of 4-(3-amrno-pyridm-2-yl)-piperazme-l-carboxylic acid tert-butyl ester (2,0 g, 7.18 mmol), acetaldehyde (0.81 mL, 0.014 mol) and methanol (30 mL) was added sodium cyanoborohydride (1.36 g, 0.022 mol). The reaction mixture was stirred at room temperature for 2 days and then diluted with ethyl acetate, washed with water and washed with brine. The organic layer was separated, dried over sodium sulfate, filtered and concentrated. The residue was purified on silica gel using hexanes: ethyl acetate (80:20) to give 4-(3-ethylamino-pyridm-2-yl)-piperazme-l-carboxylic acid tert-butyl ester (2.0 g, 91 %). GC/MS mfz 306, 223, 162, 150, 137, 120, 57.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111669-25-1, 1-Boc-4-(3-Aminopyridin-2-yl)piperazine.
Reference:
Patent; ASTRAZENECA AB; WO2008/112440; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem