Brief introduction of 116026-94-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 116026-94-9, tert-Butyl (3-formylpyridin-2-yl)carbamate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 116026-94-9 ,Some common heterocyclic compound, 116026-94-9, molecular formula is C11H14N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of the aldehyde (0.222 g, 1 mmol) and DMF (3 mL) was added MeI (0.178 g, 1.25 mmol) at 0 0C. NaH (0.052 g, 60% mineral oil, 1.35 mmol) was added in three portions over 15 min and the resulting yellowish suspension was stirred for an additional 60 min. The mixture was warmed to rt and quenched by the addition Of NaHCO3 (10 mL) and H2O (10 mL). The mixture was extracted with Et2O (3><1 OmL), and the combined organic layers were washed with H2O (10 mL), NaHCO3 (10 mL), brine (10 mL), and dried over Na2SO4. The product was further purified by flash chromatography (25% EtOAc in hexanes) to afford an oil (0.197 g, 84%), which was used in the next step

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 116026-94-9, tert-Butyl (3-formylpyridin-2-yl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LAUTENS, Mark; YUEN, Josephine; FANG, Yuanqing; WO2008/22467; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem