Synthetic Route of 131747-43-8 ,Some common heterocyclic compound, 131747-43-8, molecular formula is C7H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 64. a) To a stirred solution of 2-trifiuoromethyl nicotinic acid (0.38 g, 2 mmol) in dimethylformamide (10 mL) at room temperature was added 1,1-carbonyldiimidazole (0.34 g, 2.10 mmol) in one portion. The resulting yellow mixture was allowed to stir for ninety minutes whereupon 3,4-bis(benzyloxy)-N’-hydroxy-5-nitrobenzamidine (0.79 g, 2 mmol) was added in one portion. The resulting mixture was stirred at room temperature for two hours and then poured onto water (100 mL). The resulting precipitate was filtered off, washed with water and dried. After recrystallisation from dichloromethane/isopropanol 3 ,4-bis(benzyloxy)-5-nitro-N’-(2- (trifluoromethyl)nicotinoyloxy)benzimidamide was obtained, as a light yellow solid, 0.88 g (78%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 131747-43-8, 2-Trifluoromethylnicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PORTELA & CA. S.A.; WO2007/13830; (2007); A1;,
Pyridine – Wikipedia,
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