With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.942947-94-6, name is 5-Bromo-4-chloropyridin-2-amine, molecular formula is C5H4BrClN2, molecular weight is 207.4557, as common compound, the synthetic route is as follows.Product Details of 942947-94-6
To a 1 L 3 necked round-bottomed flask equipped with a magnetic stirrer, heating mantle, and N2 inlet was added 5-bromo-4-chloropyridin-2 -amine (25 g, 121 mmol) and sodium hydrogen sulfide hydrate (26.5 g, 362 mmol). The flask was evacuated and purged with N2 three times. To the solids, N2 sparged l-methyl-2-pyrrolidinone (250 mL) was added. The green suspension was heated to 70 C for 17 hours. The suspension was cooled to room temperature. A cooled bleach scrubber containing 750 mL of bleach was installed and to the suspension concentrated HCl (24.90 mL, 301 mmol) was added. Gas evolution was noted. The resulting dark brown/red suspension was sparged with N2 for 30 minutes. The solids were removed under N2 filtration and were washed with N2 sparged ethanol (100 mL) to give a solution of 2-amino-5-bromopyridine-4-thiol (350 mL) which was used directly in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,942947-94-6, 5-Bromo-4-chloropyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; ABBVIE INC.; KALLEMEYN, Jeff M.; KU, Yi-Yin; MULHERN, Mathew M.; WO2015/157360; (2015); A1;,
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