Reference of 115473-15-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride. A new synthetic method of this compound is introduced below.
Under nitrogen protection,A solution of 25.7 g (100 mmol) of 1-cyclopropyl-2-bromo-2- (2-fluorophenyl)2-oxo-2,4,5,6,7-7a-tetrahydrothieno [3,2-c] pyridine hydrochloride (28.7 g, 150 mmol)73 g (30 mmol) of cuprous iodide,Xphos 28.6 g (60 mmol), sodium carbonate 42.4 g (400 mmol) in 250 ml reaction flask, in 200 ml of 1,4-dioxane60 C for 3 hours. After the reaction, the mixture was cooled to room temperature, poured into ice water, extracted with methylene chloride, saturated sodium thiosulfateThe organic phase was concentrated and the mixture was recrystallized from dichloromethane and petroleum ether (1: 10) to give 5- (alpha-cyclopropylcarbonyl-2-fluorobenzyl)2-oxo-2,4,5,6,7,7a-tetrahydrothieno [3,2-c] pyridine in a yield of 90.2% and a purity of 99.37%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Qingdao Chenda Biological Science & Technology Co., Ltd.; Chen, Linghao; (8 pag.)CN106117240; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem