As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, molecular formula is C8H10ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
To a solution of 0.25 mmol (0.036 g) triethylenetetramine in10 mL methanol, 0.5 mmol (0.1 g) of pyridoxal chloridrate and1.3 mmol (136 mL) triethylamine were added. The solution was heated in an oil-bath at 55 C and stirred by 15 min. Then a solution of 0.25 mmol (0.091 g) of Ni(ClO4)26H2O in 5 mL methanol was dropped to the main solution, which was stirred at 55 C by 1 h. The slow evaporation of the solvent afforded orange crystals after 4days. A similar one-pot synthesis was already reported [13].Yield: 65%. Melting point: 118e119 C. Anal. Calc: C22H34N6O6Ni:C, 49.19; H, 6.33; N,15.65. Found: C, 49.12, H, 6.39; N,15.44%. IR (KBrpellets, cm1): 3526 [m, n(OeH)alcohols]; 3302 [m, n(OeH)alcohol];2921 [w, n(CeH)sp3)]; 1637 [s, n(C]N)]; 1312 [m, n(OeH)alcohol]1263 [m, n(CeO)phenol.]; 1201[s, n(CleO)percholate]; 1012 [s,n(CeO)alcohols].
With the rapid development of chemical substances, we look forward to future research findings about 65-22-5.
Reference:
Article; Back, Davi Fernando; De Oliveira, Gelson Manzoni; Fontana, Liniquer Andre; Ramao, Brenda Fiorin; Roman, Daiane; Iglesias, Bernardo Almeida; Journal of Molecular Structure; vol. 1100; (2015); p. 264 – 271;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem