Synthetic Route of 571189-49-6 ,Some common heterocyclic compound, 571189-49-6, molecular formula is C10H16N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: The mixture of intermediate d (0.5mmol), intermediate e (0.55mmol), Pd(OAc)2 (0.05mmol), X-phos or Xantphos (0.15mmol), Cs2CO3 (1.25mmol) and 1,4-dioxane or DME were refluxed under argon atmosphere for 1 h-4 h. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography to produce title compound A or B.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 571189-49-6, 5-(4-Methylpiperazin-1-yl)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zhang, Hao; Wang, Jin; Shen, Ying; Wang, Hui-Yan; Duan, Wei-Ming; Zhao, Hong-Yi; Hei, Yuan-Yuan; Xin, Minhang; Cao, Yong-Xiao; Zhang, San-Qi; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 221 – 237;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem