Electric Literature of 7356-60-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-(3,5-Dibromophenyl)-1-(4-pyridin-3-ylphenyl)-acetone 3-(3,5-Dibromo-phenyl)-1-(4-pyridin-3- Yl-phenyl)-propanone (34 g, 76.73 mmole), 3-Amidinopyridinium chloride (18.02 g, 11.43 mmole),Potassium phosphate (57g, 268.56mmole),And 340 ml of xylene was placed in a reaction flask and heated to maintain a reflux of 140 C.After the reaction is completed, the temperature is lowered to 90 C.After adding 100 ml of deionized water and stirring for 5 minutes, the water layer was removed.After concentrating the organic layer until the solid precipitates,The solid was washed with ethyl acetate and filtered to give a white solid.After drying, 22 g of white solid 4-(3,5-dibromophenyl)-2-pyridin-3-yl-6-(4-pyridin-3-ylphenyl)-pyrimidine (4-(3, 5-Dibromo-phenyl)-2-pyridin-3-yl-6-(4-pyridin-3-yl-phenyl)-pyrimidine),The yield was 52.69%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7356-60-7, Nicotinimidamide hydrochloride.
Reference:
Patent; E-ray Optoelectronics Technology Co Ltd; Huang, Heh Lung; Guo, Huang Ming; Chao, Teng Chih; Lin, Chi Jen; Chang, Min Jong; (53 pag.)TW2019/30287; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem