The origin of a common compound about Methyl 2-chloro-6-methylnicotinate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53277-47-7, Methyl 2-chloro-6-methylnicotinate, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53277-47-7, name is Methyl 2-chloro-6-methylnicotinate, molecular formula is C8H8ClNO2, molecular weight is 185.61, as common compound, the synthetic route is as follows.Safety of Methyl 2-chloro-6-methylnicotinate

[413] Step B: 2-isopropylsulfanyl-6-methyl-nicotinic acid methyl ester [414] 2-Chloro-6-methyl-nicotinic acid methyl ester (1.39 g, 7.44 mmol) obtainedin Step A was dissolved in DMF (15 mL). Cs2CO3 (4.88 g,14.99 mmol) and propane-2-thiol (1.39 mL, 14.99 mmol)were added to the solution, and the mixture was stirred at room temperature for2 hours. The reactant was concentrated under reduced pressure to remove thesolvent. The residue was added with water and then extracted with EtOAc. Theorganic layer was dried with MgSO4, filtered and concentrated underreduced pressure. The obtained residue was purified by column chromatography(eluent EtOAc/Hex = 1/5) to obtain the title compound (1.17 g, 69%).[415] NMR: 1H-NMR (CDCl3) 8.06(1H, d), 6.86(1H, d),4.15(1H, m), 3.90(3H, s), 2.53(3H, s), 1.40(6H, d)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53277-47-7, Methyl 2-chloro-6-methylnicotinate, and friends who are interested can also refer to it.

Reference:
Patent; LG LIFE SCIENCES LTD.; KIM, Young Kwan; KIM, Myoung Yeol; PARK, Sang Yun; PARK, Ok Ku; ARTEMOV, Vasily; LEE, Sang Dae; JOO, Hyun Woo; CHOI, Eun Sil; WO2014/69963; (2014); A1;,
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