Application of 117519-08-1, Adding some certain compound to certain chemical reactions, such as: 117519-08-1, name is 2-Chloro-3-nitro-6-(trifluoromethyl)pyridine,molecular formula is C6H2ClF3N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117519-08-1.
A solution of 2-chioro-3-nitro-6-(trifiuoromethyl)pyridine (2.0 g, 8.8 mmoi) and 6-aninobenzo[d]thiazoi-2(3H?)-one (1.5 g, 8.8 mmol) in DMF (40 ml.) was heated at 110 0Q After 3h. sodium dithionite (6.1 g, 35.3 mmoi) was added to the mixture was let stir at 110 cc for 5 h. Thereaction was diluted with water (320 mL) and let stir for 20 mm where precipitate formed. Thereaction was filtered and the solid was washed with H20 and oven dried at 45 C to give the desiredcompound as a solid (2.6 g, 90%). MS (ESI): mass caicd. for C,3HF3N4OS, 326.05 rn/z found, 327.0 [M++{]t.
According to the analysis of related databases, 117519-08-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
Pyridine – Wikipedia,
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