Extracurricular laboratory: Synthetic route of 2-Chloro 3-methylpyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18368-76-8, 2-Chloro 3-methylpyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 18368-76-8, 2-Chloro 3-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro 3-methylpyridine, blongs to pyridine-derivatives compound. Safety of 2-Chloro 3-methylpyridine

The compound 5 (1 mmol),The compound 2-chloro-3-methylpyridine (1 mmol)Dissolved in NMP (10 mL)CuI (20 mmolpercent) was added,Pd (PPh3) 2Cl2 (5 mmolpercent),DIEA (5 mmol).Under nitrogen protection,60 reaction 12h.TCL monitoring reaction is complete,Extracted three times with ethyl acetate,Combine organic phase,Washed twice with saturated NaCl,Anhydrous Na2SO4 dry.Spin dry,Column chromatography gave compound 7j.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18368-76-8, 2-Chloro 3-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Second Military Medical University, PLA; Yantai Dongcheng Pharmaceutical Industry Group Co., Ltd.; Zhang, Dazhi; Jiang, Yuanying; Niting, Junhong; Cai, Zhan; Pang, Lei; Xie, Fei; Li, Ran; Han, Haibing; He, Yan; You, Shouyi; Yang, Zhenqiu; Qi, Dongqi; (36 pag.)CN106336383; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem