Related Products of 1035123-89-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1035123-89-7, name is 3-(6-Bromopyridin-3-yl)acrylic acid, molecular formula is C8H6BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 3: 3-(6-Bromo-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (63 mg, 0.219 mmol) was suspended in THF and treated with triethylamine (25 mg, 0.241 mmol) and then the resulting mixture was stirred for 10mins. 3-(6-Bromo-pyridin-3-yl)-acrylic acid (50 mg, 0.219 mmol) was added to the reaction mixture followed by DMTMM (66 mg, 0.241 mmol) after 10 mins. The resulting mixture was stirred overnight at ambient temperature and then diluted with EtOAc. The resulting solution was washed successively with water, sat’d NaHCO3 (x2), and brine, and then dried over anhyd. Na2SO4, filtered and concentrated under reduced pressure. The crude residue was recrystallized (EtOAc/n-Hexane) to yield the title compound (71 mg, 72 %). 1H NMR (300 MHz, DMSO-d6): delta 9.42 (s, 1H), 8.77 (t, 1H, J = 6.0 Hz), 8.60 (d, 1H, J = 2.4 Hz), 7.96 (dd, 1H, J = 8.1, 1.8 Hz), 7.70 (d, 1H, J = 8.1 Hz), 7.48 (d, 1H, J = 15.9 Hz), 7.28 (s, 1H), 7.27 (d, 1H, J = 8.7 Hz), 6.81 (d, 1H, J = 15.9 Hz), 4.50 (s, 1H), 4.39 (d, 2H, J = 5.7 Hz), 3.06 (s, 3H). ESI [M+H]+; 452.0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1035123-89-7, 3-(6-Bromopyridin-3-yl)acrylic acid.
Reference:
Patent; Amorepacific Corporation; EP1882687; (2008); A1;,
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