Related Products of 6443-85-2 ,Some common heterocyclic compound, 6443-85-2, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a Schlenk tube,116 mg (0.151 mmol) of 1 was dissolved in 10 mL of CH2Cl2, resulting in a bright-red solution. 160 muL (179 mg, 1.51 mmol) of 3-pyridylacetonitrile (3-Py-CH2CN) was syringed into the solution, and the reaction mixture was stirred at room temperature for 7 h. After this time, the solvent was evaporated to dryness and the solid residue was washed three times with hexane. The final product was characterized as 2. Yield: 100.8 mg, 0.139 mM,92%. IR (ATR): nu 2535vs (BH), 2511vs (BH), 2460vs (BH), 2255w (CN), and 2060m(RhH). 11B-{1H} NMR (128 MHz; CD2Cl2; 298 K): delta + 12.1, +7.8, +3.5, +0.3, -3.8, -9.9,-18.5, -25.6, and -29.6. 1H NMR (500 MHz; CD2Cl2; 298 K): delta + 7.91 (1H, br,3-PyCH2CN), +7.82 (1H, br, 3-PyCH2CN), +7.35 – +7.05 (aromatics, PPh3), +4.04 (v br,BH), +3.67 (ABq, 1H, DeltanuAB = 30.8 Hz, JAB = 19.2 Hz, CH2CN), +3.55 (ABq, CH2CN),+2.85 (v br, BH), +1.84 (v br, BH), -1.37 (br s, BHB), and -12.51 (apparent q, J = 18.9 Hz, RhH); due to the insolubility of the compound, the terminal B-H peakscould not be observed. 31P-{1H} NMR (121 MHz; CD2Cl2; 213 K): delta + 36.3 (dd,JRhP = 104.1 Hz) and + 30.4 (dd, JRhP = 127.1 Hz, 2JPP = 19 Hz). LRMS (MALDI+/DCTB): m/z [2M-3(PPh3)-4H]+ obsvd 979, Calcd for P1C32H43Rh2S2B18N4: 979; [M-PPh3-2H]+ obsvd 621, Calcd for P1C25H29Rh1S1B9N2: 621. The obsvd isotope envelope matchesthat calculated from the known isotopic abundances of the constituent elements.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6443-85-2, its application will become more common.
Reference:
Article; Calvo; Kess; Macias; Sancho; Lahoz; Oro; Journal of Coordination Chemistry; vol. 67; 23-24; (2014); p. 4016 – 4027;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem