Synthetic Route of 98198-48-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 98198-48-2, name is 2-Amino-5-bromo-4-methylpyridine. A new synthetic method of this compound is introduced below.
Synthesis 21 5-Bromo-4-methy -1-oxy-pyridin-2-ylamine hydrochloride 5-Bromo-4-methyl-pyridin-2-ylamine (22 mmol, 4.1 1 g) was dissolved in acetone (40 mL) and cooled to 0 C and then treated with m-CPBA (44 mmol, 7.59 g). The reaction mixture was allowed to stir at room temperature for 2 hours and then evaporated under reduced pressure to an orange solid. This was dissolved in chloroform cooled to 0 C and treated portion-wise with 2 M ethereal hydrogen chloride (40 mL). The cooling bath was removed and the suspension was stirred at room temperature for 3 hours. The solid precipitate was filtered off and washed with ether (1×10 mL). The solid was dried under reduced pressure to provide the title compound as beige solid. Yield: 5.27 g, 100%. LCMS, analytical method 1 , TR=2.43 mins, 100%, MI+H=203/205. H NMR (300 MHz, DMSO-d6) delta: 8.64 (1 H, s), 8.30 (2 H, m), 7.05 (1 H, s), 2.32 (3 H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98198-48-2, its application will become more common.
Reference:
Patent; CHARLES, Mark David; BROOKFIELD, Joanna Lola; EKWURU, Chukuemeka Tennyson; STOCKLEY, Martin Lee; WO2015/25172; (2015); A1;,
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