Application of 1001413-01-9, Adding some certain compound to certain chemical reactions, such as: 1001413-01-9, name is 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid,molecular formula is C13H9F2NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001413-01-9.
Compound 25.5 (0.168 grams, 0.749), l-(3,4-difluoro-benzyl)-2-oxo-l,2-dihydro- pyridine-3-carboxylic acid (0.200 grams, 0.749 mmol), N-(3-dimethylaminopropyl)-N’- ethylcarbodiimide hydrochloride (0.172 grams, 0.899 mmol) and 1-hydroxybenzotriazole monohydrate (0.138 grams, 0.899 mmol), and diisopropylethylamine (0.652 ml, 3.75 mmol) were dissolved in dimethylacetamide (4 ml) and stirred at ambient temperature for 17 hours. The reaction was diluted with EtOAc, washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered, and concentrated. The residue was purified by column chromatography on silica (3% MeOH/DCM) to yield Compound 25.6 (0.066grams, 0.140 mmol, 19%). ES (+) MS m/e = 472 (M+l). IH NMR (400 MHz, DMSO-d6) delta ppm 4.59 (m, 2 H) 5.20 (m, 2 H) 6.58 (m, 1 H) 7.14 (m, 2 H) 7.40 (m, 2 H) 8.00 (m, 1 H) 8.08 (m, 1 H) 8.22 (m, 1 H) 8.29 (m, 2 H) 8.39 (m, 2 H) 8.84 (m, 1 H) 10.11 (m, 1 H) 12.06 (m, 1 H).
According to the analysis of related databases, 1001413-01-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.; WO2008/5457; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem