The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 66572-56-3, name is 2-Bromoisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Bromoisonicotinic acid
At 20 C,5.0 g of 2-bromopyridine-4-carboxylic acid (24.9 mmol, 1.0 eq), 4.46 g of CuCN (49.8 mmol, 2.0 eq), 50 mL of DMF was added to a 100 mL single-mouth bottle, replaced with nitrogen three times, and heated in an oil bath at 120 C for 18 h. The heating was stopped, cooled to room temperature, and most of the DMF was removed by rotary evaporation, poured into water, extracted with EA 200 mL three times, and the organic phase was washed twice with 50 mL of water and 20 mL of saturated sodium chloride. The organic phase is dried and dried to give a crude product. 2.0g crude product as a white solid after recrystallization from methanol,Yield: 54.2%.
With the rapid development of chemical substances, we look forward to future research findings about 66572-56-3.
Reference:
Patent; Jinan Shaoyuan Pharmaceutical Co., Ltd.; Shaoyuan Science And Technology (Shanghai) Co., Ltd.; Wang Haibo; Pan Tingting; Zheng Yan; (7 pag.)CN109836379; (2019); A;,
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