Adding a certain compound to certain chemical reactions, such as: 717106-69-9, Methyl 2-(6-chloropyridin-3-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 717106-69-9, blongs to pyridine-derivatives compound. Product Details of 717106-69-9
General procedure: To a solution of 1,4-dibromobutane (4.88g, 22.5mmol) and methyl 2-(6-chloropyridin-3-yl)acetate (2.79g, 15.0mmol) in THF (150mL) was added a 1.0M solution of LHMDS in THF (18.8mL, 18.8mmol) dropwisely at 0C. The reaction mixture was stirred at rt for 2.0h, then was added a 1.0M solution of LHMDS in THF (18.8mL, 18.8mmol) slowly at rt. The reaction mixture was stirred at rt overnight, quenched with brine, and extracted with ethyl acetate (30mL, 3×). The combined organic layers were dried (MgSO4) and concentrated under reduced pressure. The resulting residue was purified by column chromatography with pre-packed silica gel disposable column to afford the title compound 2a (2.26g, 63%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,717106-69-9, Methyl 2-(6-chloropyridin-3-yl)acetate, and friends who are interested can also refer to it.
Reference:
Article; Zhang, Dehui; Zheng, Hongchao; Wang, Xiaodong; Tetrahedron; vol. 72; 16; (2016); p. 1941 – 1953;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem