As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14254-57-0, name is Isonicotinoyl chloride, molecular formula is C6H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Isonicotinoyl chloride
General procedure: 1 equiv of cinnamamide was dissolved in dry DCM followed byaddition of 3 equiv of Et3N and stirred at 0 C under inert atmosphere.1.5 equiv of isonicotinoyl chloride dissolved in DCM wasdirectly added dropwise to above stirred solution at 0 C. The reactionmixture was stirred for 0.5 h. The reaction progress was monitoredby TLC. After completion of the reaction, the reaction mixturewas diluted with water (30 ml) and extracted with DCM twice. Theorganic layer was washed successively with saturated bicarbonatesolution (220 ml) and brine solution (20 ml). The organic layerwasdried over anhydrous sodium sulfate and was evaporated underreduced pressure. The crude product was recrystallized from ethylacetate and hexane to afford the desired product.
With the rapid development of chemical substances, we look forward to future research findings about 14254-57-0.
Reference:
Article; Patel, Kavitkumar N.; Telvekar, Vikas N.; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 43 – 56;,
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