Analyzing the synthesis route of 2-Methoxynicotinic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16498-81-0, 2-Methoxynicotinic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 16498-81-0, 2-Methoxynicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H7NO3, blongs to pyridine-derivatives compound. COA of Formula: C7H7NO3

Step 2 Preparation of N-[2-(7,8-Dimethyl-2,4-dioxo-3,4-dihvdro-2H-benzo[glpteridin- 10-vD-ethyll-2-methoxy-nicotinamide; [0116] 2-Methoxy-nicotinic acid (20 mg, 0.12 mmol) and Hunig’s base (0.024 mL,0.14 mmol) are dissolved in DMF (1 mL) followed by addition of HATU (53 mg, 0.14 mmol) at room temperature and is stirred for one hour. 10-(2-Amino-ethyl)-7,8-dimethyl- 10H-benzo[g]pteridine-2,4-dione (39 mg, 0.14 mmol) (see Intermediate 1 for preparation) is dissolved in DMF (ImL) and added to the reaction mixture. After 3 h the reaction mixture is diluted with water (2 mL) and purification is performed using preparatory HPLC (Method 3). 3-[2-(7,8-Dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10- yl)-ethylamino] -benzoic acid (12 mg) is isolated following lyophilization of the appropriate fractions (Yield: 24%). 1H NMR (400 MHz, DMSO-d6) delta 11.37 (s, 1H), 8.48 (m, 1H), 8.28 (m, 1H)5 8.02 (m, 1H), 7.89 (m, 2H), 4.81 (m, 2H), 3.78 (m, 5H), 2.33 (s, 3H), 2.30 (s, 3H). LC-MS m/z 421.2 [M+H]+. Retention time = 5.31 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16498-81-0, 2-Methoxynicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; BIORELIX, INC.; COISH, Philip, D.G.; WICKENS, Philp; AVOLA, Stephanie; BABOULAS, Nick; BELLO, Angelica; BERMAN, Judd; KAUR, Harpreet; MOON, David; PHAM, Vinh; ROUGHTON, Andrew; WILSON, Jeffrey; ARISTOFF, Paul, Adrian; BLOUNT, Kenneth, F.; DIXON, Brian, R.; MYUNG, Jayhyuk; OSTERMAN, David; BELLIOTTI, Thomas, R.; CHRUSCIEL, Robert, A.; EVANS, Bruce, R.; LEIBY, Jeffrey, A.; SCHOSTAREZ, Heinrich, J.; UNDERWOOD, Dennis; NAVIA, Manuel; SCIAVOLINO, Frank; WO2011/8247; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem