With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58539-77-8, name is 3-(Chloromethyl)-2-methylpyridine hydrochloride, molecular formula is C7H9Cl2N, molecular weight is 178.06, as common compound, the synthetic route is as follows.Product Details of 58539-77-8
To the mixture of methyl 2-(4-aminopiperidin-1-yl)acetate hydrochloride (190 mg, 0.78 mmol) and 3-(chloromethyl)-2-methylpyridine hydrochloride (151 mg, 0.85 mmol) in DMF (3 mL) was added K2CO3 (428 mg, 3.1 mmol) and potassium iodide (64.3 mg, 0.38 mmol), then the mixture was heated at 60 C overnight under argon protection. The reaction mixture was cooled to rt and poured into water (10 mL), and extracted with EtOAc. The combined organic layers were washed with brine, and dried over Na2SO4. The organic solvents were removed under vacuum, and the residue was purified by silica gel column chromatography (0-100% ethyl acetate/hexanes) to give the title compound as a colorless oil (100 mg, 46.3%) MS: 278 [M+H]+;
At the same time, in my other blogs, there are other synthetic methods of this type of compound,58539-77-8, 3-(Chloromethyl)-2-methylpyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19621; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem