Adding a certain compound to certain chemical reactions, such as: 944401-69-8, 5-Bromo-4-fluoropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 944401-69-8, blongs to pyridine-derivatives compound. COA of Formula: C5H4BrFN2
A suspension of 5-bromo-4-fluoropyridin-2-amine (1 g, 5.24 mmol) inisopropanol (10 mL) was treated with 1-bromo-2,2-dimethoxypropane (1.16 g, 6.28mmol). The resulting mixture was heated at 80C for 21 h, then cooled to room temperature and concentrated under vacuum at 40C. The residue was treated with ethyl acetate (15 mL) and water (15 mL) and the phases were separated. The aqueous phase was basified with aqueous NaOH solution (32% w/w) to pH 8, then extracted with ethylacetate (10 mL, then 15 mL). The organic phases were pooled and concentrated under vaccuum at 40C to give the title compound (0.93 g, 78%) as a beige solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,944401-69-8, its application will become more common.
Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; BENTLEY, Jonathan Mark; BRACE, Gareth Neil; BROOKINGS, Daniel Christopher; CHOVATIA, Praful Tulshi; DEBOVES, Herve Jean Claude; JOHNSTONE, Craig; JONES, Elizabeth Pearl; KROEPLIEN, Boris; LECOMTE, Fabien Claude; MADDEN, James; MILLER, Craig Adrian; PORTER, John Robert; SELBY, Matthew Duncan; SHAW, Michael Alan; VAIDYA, Darshan Gunvant; YULE, Ian Andrew; WO2015/86506; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem