Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 178876-82-9, name is Methyl 6-amino-5-bromopicolinate. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H7BrN2O2
a) Methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-/?][1 ,4]thiazine-6-carboxylate A solution of ethyl 2-mercaptoacetate (1.473 mL) in DMF (48 ml_) was ice-cooled and treated with sodium hydride (540 mg of a 60% dispersion in oil). After 1 hour methyl beta-amino-delta-bromopyridine^-carboxylate (3 g) (T.R. Kelly and F. Lang, J. Org. Chem. 61, 1996, 4623-4633) was added and the mixture stirred for 16 hours at room temperature. The solution was diluted with EtOAc (1 litre), washed with water (3 x 300 mL), dried and evaporated to about 10 mL. The white solid was filtered off and washed with a little EtOAc to give the ester (0.95g); MS (APCI”) m/z 223 ([M-H]”, 100%).
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Reference:
Patent; GLAXO GROUP LIMITED; WO2006/17468; (2006); A2;,
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