Related Products of 1382486-27-2 ,Some common heterocyclic compound, 1382486-27-2, molecular formula is C10H10BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of l-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid (16.9 g, 66.0 mmol) in i-BuOH (30 mL) was added TEA (17.5 mL, 125 mmol) and DPPA (23.6 g, 86 mmol) at RT. After the addition was finished, the reaction was stirred at 85 C under nitrogen for 18 h. After 18 h the solvent was concentrated in vacuo. The residue was purified via column chromatography (Petroleum ether/ EtOAc =10: 1-2: 1) to afford tert-butyl (l-(5-bromopyridin-2- yl)cyclobutyl)carbamate. MS ESI calc’d. [M + H]+ 327, found 327.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1382486-27-2, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WHITE, Catherine M.; ACHAB, Abdelghani; BHARATHAN, Indu T.; FRADERA, Xavier; HAN, Yongxin; LI, Derun; LIM, Jongwon; LIU, Kun; MCGOWAN, Meredeth Ann; SCIAMMETTA, Nunzio; YU, Wensheng; ZHANG, Hongjun; ZHOU, Hua; (107 pag.)WO2019/74749; (2019); A1;,
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