Application of 73290-22-9 , The common heterocyclic compound, 73290-22-9, name is 2-Bromo-5-iodopyridine, molecular formula is C5H3BrIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
1-Ethynylferrocene (500 mg, 2.38 mmol) was dissolved in THF/TEA (20 mL, 1:1 v/v) and the solutionwas degassed (argon) for 10 minutes. 2-Bromo-5-iodopyridine (614 mg, 2.16 mmol),[Pd(CH3CN)2Cl2]2 (38 mg, 0.054 mmol) and CuI (41 mg, 0.216 mmol) were added and the mixture wasstirred at RT under inert atmosphere overnight. The reaction mixture was diluted with CH2Cl2 (50mL) and washed with EDTA/NH4OH(aq) (0.1 M, 100 mL). The organic layer was separated and theaqueous layer was extracted with CH2Cl2 (2 x 50 mL). The combined organic layers were washed withbrine (80 mL), dried over Na2SO4, filtered, and the solvent was removed under reduced pressure.Purification by column chromatography (silica gel, gradient 1:1 CH2Cl2/petrol to CH2Cl2 to 19:1CH2Cl2/acetone) gave the product as an orange crystalline solid upon removal of solvent. Yield: 0.776g, 98%.
The synthetic route of 73290-22-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Findlay, James A.; Barnsley, Jonathan E.; Gordon, Keith C.; Crowley, James D.; Molecules; vol. 23; 8; (2018);,
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